SREBF1 Rabbit anti-Mouse, Pig, Rat, Biotin, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of SREBF1.

Supplier:  Abnova Corporation PAB15203

Catalog No. 89-117-498

Description

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

• Antigen: SREBF1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of SREBF1.
• Formulation: In PBS
• Gene Alias: SREBP-1c/SREBP1/bHLHd1
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: This is specific to SREBP1. By Western blot a band is seen at ∼65KDa.
• Content And Storage: Store at 4°C. Do not freeze.

• Applications: Western Blot
• Conjugate: Biotin
• Dilution: Western Blot (2 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: SREBF1
• Gene Symbols: SREBF1
• Immunogen: A synthetic peptide corresponding to amino acids 300-400 of human SREBF1.
• Regulatory Status: RUO
• Gene ID (Entrez): 6720
• Target Species: Mouse, Pig, Rat
• Form: Liquid

For Research Use Only