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Description
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq
Specifications
Specifications
| Antigen | ST14 |
| Applications | Immunofluorescence, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of ST14. |
| Dilution | Western Blot (1:500-1:1000) Immunofluorescence (1:50-1:200) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS, pH 7.2 (0.09% sodium azide) |
| Gene | ST14 |
| Gene Alias | HAI/MT-SP1/MTSP-1/MTSP1/PRSS14/SNC19/TADG-15 |
| Gene Symbols | ST14 |
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