MilliporeSigma™ Rabbit anti-Stearoyl-CoA desaturase 1, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABN1003

Catalog No. ABN1003MI

Description

Specifically detects Stearoyl-CoA desaturase 1 in Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunohistochemistry

Fatty acid desaturases (FADS) catalyze the formation of carbon/carbon double bonds in fatty acids. Stearoyl-CoA desaturase 1 (Scd1), in particular, is an FADS that catalyzes the synthesis of oleic acid by introducing a double bond between C9 and C10 from the carboxyl end of stearic acid. Scd1 activity is essential for the earliest step of autophagosome formation, whose membrane has a high content of unsaturated fatty acids. Scd1 is reported to regulate inflammatory gene expression in adipocytes by influencing DNA methylation at the CpG promoter sites, Scd1 overexpression or silencing results in global DNA hypomethylation or hypermethylation, respectively, in 3T3 adipocytes. Stearoyl-CoA desaturase 1 is a novel therapeutic target in various malignancies, including breast cancer. (PMID 25130896, 25023287, and 25013434). Anti-Stearoyl-CoA desaturase 1, is a purified rabbit polyclonal raised against murine Scd1 (UniProt P13516 & Q547C4) C-terminal sequence that is well conserved in rat (UniProt P07308), but not in human.

Specifications

• Antigen: Stearoyl-CoA desaturase 1
• Classification: Polyclonal
• Gene Accession No.: Q547C4
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Mouse, Rat

• Applications: Immunocytochemistry, Immunohistochemistry
• Formulation: Purified rabbit polyclonal in buffer containing PBS without preservatives.
• Gene Symbols: Scd1
• Immunogen: Linear peptide corresponding to mouse Stearoyl-CoA desaturase 1.
• Quantity: 50 μL
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_033153
• Content And Storage: Stable for one year at -80°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.

For Research Use Only