MilliporeSigma™ Rabbit anti-Tau, AEP-cleaved (N368), Polyclonal,

Catalog No.	Quantity
ABN1703MI	100 μL

Catalog No. ABN1703MI Supplier MilliporeSigma™ Supplier No. ABN1703

Description

Rabbit Polyclonal Antibody

Specifically detects Tau, AEP-cleaved (N368) in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Microtubule-associated protein Tau (UniProt P10636; also known as Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau) is encoded by the MAPT (also known as TAU, MAPT1, MTBTL) gene (Gene ID 4137) in human. Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated Tau, are a common feature of aging-related neurodegenerative diseases, including Alzheimer's disease (AD). In addition to caspases-mediated cleavage at Asp421, Tau can also be cleaved at Asn255 and Asn368 by the lysosomal cysteine proteinase asparagine endopeptidase (AEP). AEP is upregulated in aged brain, as well as n human AD brain and tau P301S–transgenic mice with synaptic pathology and behavioral impairments. AEP-mediated tau cleavage abolishes tau microtubule assembly function, induces tau aggregation and triggers neurodegeneration. AEP knockout or functional blockage in tau P301S mice leads to a reduction of tau hyperphosphorylation, protection against memory loss, and a reduction in tau P301S–triggered pathological and behavioral defects.

Specifications

• Antigen: Tau, AEP-cleaved (N368)
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
• Gene Accession No.: P10636
• Gene Symbols: MAPT; MAPTL; MTBT1; TAU
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human Tau, AEP-cleaved (N368).
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Neuroscience
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_005901
• Target Species: Human, Mouse, Rat
• Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
• Form: Serum

For Research Use Only