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TERT (phospho S1125), Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89131649 Shop All Abnova Corporation Products
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400 μL
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89-131-649 400 μL
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Catalog No. 89-131-649 Supplier Abnova Corporation Supplier No. PAB4934
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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of TERT.

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq

Specifications

Antigen TERT
Applications Dot Blot, ELISA
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of TERT.
Dilution ELISA (1:1000) Dot Blot (1:500) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene TERT
Gene Alias EST2/TCS1/TP2/TRT/hEST2
Gene Symbols TERT
Host Species Rabbit
Immunogen Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S1125 of human TERT.
Purification Method Protein A purification
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7015
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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