MilliporeSigma™ Rabbit anti-TERT, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABE2075

Catalog No. ABE2075

Description

Specifically detects TERT in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunohistochemistry, Western Blotting

Telomerase reverse transcriptase (EC 2.7.7.49; UniProt O14746; also known as hEST2, hTRT, Telomerase-associated protein 2, Telomerase catalytic subunit, TP2) is encoded by the TERT (also known as CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TRT) gene (Gene ID 7015) in human. Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the telomerase. It is responsible for adding TTAGGG repeats to the chromosome telomere ends, which is an important event in maintaining cell immortality. The hTERT expression level is very low in most normal human cells, wherease greater than 90 % of human tumor cells of different pathology and origins are shown to display up-regulated telomerase expression, making hTERT a target for cancer therapy.

Specifications

• Antigen: TERT
• Classification: Polyclonal
• Gene Accession No.: O14746
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat

• Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: TERT; CMM9; DKCA2; DKCB4; EST2; PFBMFT1; TCS1; TRT
• Immunogen: KLH-conjugated linear peptide corresponding to a sequence from the C-terminal extension (CTE) region of human TERT.
• Quantity: 100 μg
• Research Discipline: Epigenetics and Nuclear Function
• Gene ID (Entrez): NP_937983
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only