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TLR4 Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Catalog No. 89117618 Shop All Abnova Corporation Products
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100 μg
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89-117-618 100 μg
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Catalog No. 89-117-618 Supplier Abnova Corporation Supplier No. PAB15432
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Description

Rabbit polyclonal antibody raised against synthetic peptide of TLR4.

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq

Specifications

Antigen TLR4
Applications Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of TLR4.
Dilution Western Blot (1-3 ug/mL) Immunohistochemistry (1:50) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.05% BSA, 0.09% sodium azide)
Gene TLR4
Gene Alias ARMD10/CD284/TOLL/hToll
Gene Symbols TLR4
Host Species Rabbit
Immunogen A synthetic peptide corresponding to amino acids 420-435 of human TLR4.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7099
Test Specificity Detects ∼75-80KDa when tested against partial recombinant mouse TLR4 (extra-cellular portion plus His-tag).
Target Species Human, Mouse
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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