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TNFSF11 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89116745 Shop All Abnova Corporation Products
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100 μg
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Catalog No. Quantity
89-116-745 100 μg
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Catalog No. 89-116-745 Supplier Abnova Corporation Supplier No. PAB13566

Description

Rabbit polyclonal antibody raised against recombinant TNFSF11.

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq

Specifications

Antigen TNFSF11
Applications ELISA, Flow Cytometry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against recombinant TNFSF11.
Dilution ELISA (1:2000-1:10000) Flow Cytometry (1:500-1:1000) Western Blot (1:2000-1:5000) The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.4
Gene TNFSF11
Gene Alias CD254/ODF/OPGL/OPTB2/RANKL/TRANCE/hRANKL2/sOdf
Gene Symbols TNFSF11
Host Species Rabbit
Immunogen Recombinant protein corresponding to human TNFSF11.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8600
Test Specificity Recognizes human RANKL. Detects a band of ∼35 KDa by Western blot.
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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