TNK2 (phospho Y284), Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human TNK2.

Supplier:  Abnova Corporation PAB29267

Catalog No. 89-130-704

Description

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq

Specifications

• Antigen: TNK2
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of human TNK2.
• Formulation: In PBS (without Mg²⁺ and Ca²⁺), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene Alias: ACK/ACK1/FLJ44758/FLJ45547/p21cdc42Hs
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10188
• Target Species: Human
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Immunofluorescence (1:100∼1:200) Immunohistochemistry (1:50∼1:100) Western Blot (1:500∼1:1000) The optimal working dilution should be determined by the end user.
• Gene: TNK2
• Gene Symbols: TNK2
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y284 of human TNK2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: TNK2 (phospho Y284) polyclonal antibody detects endogenous levels of human TNK2 only when phosphorylated at tyrosine 284.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only