TOP2A Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-126-769	100 μL

Catalog No. 89-126-769 Supplier Abnova Corporation Supplier No. PAB25095

Description

Rabbit polyclonal antibody raised against synthetic peptide of TOP2A.

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq

Specifications

• Antigen: TOP2A
• Applications: Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of TOP2A.
• Dilution: Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) Immunofluorescence (1:50-1:200) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.2 (0.05% sodium azide)
• Gene: TOP2A
• Gene Alias: TOP2/TP2A
• Gene Symbols: TOP2A
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to TOP2A.
• Purification Method: Affinity purification
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7153
• Test Specificity: TOP2A polyclonal antibody detects endogenous levels of TOP2A protein.
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only