TOP2B Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-120-473	100 μg

Catalog No. 89-120-473 Supplier Abnova Corporation Supplier No. PAB18909

Description

Rabbit polyclonal antibody raised against synthetic peptide of TOP2B.

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq

Specifications

• Antigen: TOP2B
• Applications: ELISA, Immunohistochemistry (PFA fixed)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of TOP2B.
• Dilution: ELISA (1:5000-1:20000) Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user.
• Formulation: In buffer containing 0.02% sodium azide, 2% BSA
• Gene: TOP2B
• Gene Alias: TOPIIB/top2beta
• Gene Symbols: TOP2B
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to 15 amino acids at C-terminus of human TOP2B.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7155
• Target Species: Human
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only