TP53 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-120-484	3 X 200 μL

Catalog No. 89-120-484 Supplier Abnova Corporation Supplier No. PAB18930

Description

Rabbit polyclonal antibody raised against partial recombinant TP53.

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq]

Specifications

• Antigen: TP53
• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against partial recombinant TP53.
• Dilution: Immunohistochemistry (1:50-1:100 Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.
• Formulation: Lyophilized from tissue culture supernatant (0.09% sodium azide)
• Gene: TP53
• Gene Alias: FLJ92943/LFS1/TRP53/p53
• Gene Symbols: TP53
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to human TP53.
• Quantity: 3 X 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7157
• Target Species: Human
• Content And Storage: Store at 4°C on dry atmosphere. After reconstitution with sterile distilled water store at 4°C for at least two months. For long term storage store at -20°C or below. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized

For Research Use Only