MilliporeSigma™ Rabbit anti-TRIM11, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABC926

Catalog No. ABC926MI

Description

Specifically detects TRIM11 in Human, Mouse samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

E3 ubiquitin-protein ligase TRIM11 (UniProt Q96F44; also known as Protein BIA1, RING finger protein 92, Tripartite motif-containing 11, Tripartite motif-containing protein 11) is encoded by the TRIM11 (also known as BIA1, RNF92) gene (Gene ID 81559) in human. TRIM11 belongs to a family of more than 70 TRIM/RBCC proteins characterized by their shared tripartite motif structure, also known as the RBCC (RING finger, B-box, and coiled-coil) domain. The B-box and coiled coil regions are believed to participate in protein-protein interactions and formation of macromolecular complexes. TRIM proteins are involved in diverse cellular processes, including cell proliferation, differentiation, oncogenesis, and apoptosis. The presence of a RING domain suggests that TRIM proteins function as E3 ubiquitin ligases. The neuroprotective peptide humanin, activator-recruited cofactor (ARC) 105-kDa component (ARC105), the transcription factors Pax6 and PHOX2B are all known subrates targeted by TRIM11-mediated degradation through the ubiquitin-proteasome system. In addition, TRIM11 is also reported to interfere with the early steps of HIV-1 replication in host cells in a RING domain-dependent manner.

Specifications

• Antigen: TRIM11
• Classification: Polyclonal
• Gene Accession No.: Q96F44
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: TRIM11; RNF92
• Immunogen: KLH-conjugated linear peptide corresponding to human TRIM11.
• Quantity: 100 μg
• Research Discipline: Apoptosis, Cancer
• Gene ID (Entrez): NP_660215
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only