MilliporeSigma™ Rabbit anti-trimethyl STAT3 (Lys180), Polyclonal,

Catalog No.	Quantity
ABE1397MI	100 μL

Catalog No. ABE1397MI Supplier MilliporeSigma™ Supplier No. ABE1397

Description

Rabbit Polyclonal Antibody

Specifically detects trimethyl STAT3 (Lys180) in Mouse samples, and it is validated for Immunoprecipitation, Western Blotting

Signal transducer and activator of transcription 3 (UniProt P40763; also known as Acute-phase response factor, DNA-binding protein APRF) is encoded by the STAT3 (also known as ADMIO, APRF, HIES) gene (Gene ID 6774) in human. STAT proteins are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. STAT3 is known to be activated by IFN alpha but not IFN beta. The transcription factors associated with STAT3 are cJun and cyclic AMP responsive enhancer binding protein (CREB). STAT3 gene knockout in mice is lethal at the early embryonic stage.

Specifications

• Antigen: trimethyl STAT3 (Lys180)
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: P40763
• Gene Symbols: STAT3; APRF
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to the STAT3 K180me3 of human trimethyl STAT3 (Lys180)
• Purification Method: Affinity Purified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Epigenetics and Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_644805
• Target Species: Mouse
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only