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TYMS Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89117297 Shop All Abnova Corporation Products
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89-117-297 100 μL
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Catalog No. 89-117-297 Supplier Abnova Corporation Supplier No. PAB14837

Description

Rabbit polyclonal antibody raised against synthetic peptide of TYMS.

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq

Specifications

Antigen TYMS
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Concentration Lot specific
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of TYMS.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.4 (1% BSA, 0.09% sodium azide)
Gene TYMS
Gene Alias HsT422/MGC88736/TMS/TS/TSase
Gene Symbols TYMS
Host Species Rabbit
Immunogen A synthetic peptide corresponding to C-terminus of human TYMS.
Purification Method Immunoaffinity purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7298
Test Specificity Molecular weight: 36 KDa. Epitope: C-terminus.
Target Species Human
Content And Storage Store at 4°C. Do not freeze.
Form Liquid
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