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VAV1 (phospho Y174), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of VAV1.

Supplier:  Abnova Corporation PAB25422

Catalog No. 89-127-043


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Description

Description

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq

Sequence: E-I-Yp-E-D
Specifications

Specifications

VAV1
Polyclonal
Rabbit polyclonal antibody raised against synthetic phosphopeptide of VAV1.
In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
VAV
Rabbit
Affinity purification
RUO
7409
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Western Blot
Unconjugated
Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.
VAV1
VAV1
Synthetic phosphopeptide corresponding to residues surrounding Y174 of human VAV1.
100 μg
Primary
Human, Mouse, Rat
Liquid
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