VISA Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of VISA.

Supplier:  Abnova Corporation PAB13251

Catalog No. 89-116-498

Description

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM

Specifications

• Antigen: VISA
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of VISA.
• Formulation: In PBS (0.02% sodium azide)
• Gene Alias: CARDIF/DKFZp547C224/DKFZp666M015/FLJ27482/FLJ35386/FLJ38051/FLJ41962/IPS-1/IPS1/KIAA1271/MAVS/MGC3260
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: VISA
• Gene Symbols: VISA
• Immunogen: A synthetic peptide corresponding to N-terminus 13 amino acids of human VISA.
• Regulatory Status: RUO
• Gene ID (Entrez): 57506
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only