WNT4 Rabbit anti-Bovine, Dog, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat, Polyclonal Antibody, Abnova™

Rabbit polyconal antibody raised against synthetic peptide of WNT4.

Supplier:  Abnova Corporation PAB28375

Catalog No. 89-129-879

Description

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq

Specifications

• Antigen: WNT4
• Classification: Polyclonal
• Description: Rabbit polyconal antibody raised against synthetic peptide of WNT4.
• Formulation: In PBS (0.09% sodium azide)
• Gene Alias: SERKAL/WNT-4
• Host Species: Rabbit
• Purification Method: Immunoaffinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54361
• Target Species: Bovine, Canine, Equine, Hamster, Human, Monkey, Mouse, Porcine, Rat
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed)
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/ml) The optimal working dilution should be determined by the end user.
• Gene: WNT4
• Gene Symbols: WNT4
• Immunogen: A synthetic peptide corresponding to 14 amino acids at internal region of human WNT4.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Test Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins, except WNT5A (71%).
• Content And Storage: Store at 4°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only