Invitrogen™ Rabies Virus Monoclonal Antibody (RAB-50)

Catalog No.	Quantity
01-672-082	100 μg

Catalog No. 01-672-082 Supplier Invitrogen™ Supplier No. MA135778

Description

Mouse Monoclonal Antibody

RAb-50 reacts with SAD-Vnukovo and Pitman-Moore strains of rabies virus. It shows conformation dependent specificity for the viral envelope glycoprotein. In immunofluorescence test, SAD-Vnukovo strain is recognized by the antibody, while in Western blot, both strains are recognized by the antibody. In ELISA only SAD-Vnukovo strain is recognized. RAb-50 can neutralize the CVS strain of rabies virus.

Rabies virus (Neurotropic lyssavirus) is a member of the Rhabdoviridae family. Rabies is a single stranded, neurotropic, negative sense RNA virus which encodes 5 proteins: a glycoprotein, a nucleoprotein, and three others. The mature virus has a bullet shape, a protein coat, and a lipid envelope. The outer surface of the virus is covered with thumblike glycoprotein projections 5-10 nm long and 3 nm in diameter. The virus averages approximately 780 nm in length. Virus infectivity is destroyed by lipid solvents. Rabies virus is a very successful virus, with a very wide range of hosts. It causes an acute, central nervous system infection, characterized by CNS irritation, followed by paralysis and death. Approximately 50,000 human deaths each year are caused by rabies.

Specifications

• Antigen: Rabies Virus
• Applications: ELISA, Immunohistochemistry (Frozen), Neutralization, Western Blot
• Classification: Monoclonal
• Clone: RAB-50
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene Alias: Neurotropic lyssavirus
• Host Species: Mouse
• Immunogen: Purified virions of Rabies virus, first of SAD-Vnukova strain, followed by Pitman-Moore strain.
• Purification Method: Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Virus
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b