RAD21 Monoclonal Antibody (OTI2A12), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA811221

Catalog No. 50-168-3914

Description

The cohesin complex plays an important role in tethering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys the cohesin complex by means of cleavaging its Scc1 subunit, allowing the chromatids to separate and divide with the cell. During apoptosis the C-terminal portion of hRad21 is cleaved and translocated to the cytoplasm. This cleavage and translocation may act as a nuclear signal that promotes and accelerates subsequent events of apoptosis.

Specifications

• Antigen: RAD21
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: RAD21
• Gene Alias: CDLS4, HR21, HRAD21, MCD1, NXP1, SCC1, hHR21
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5885
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2A12
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O60216
• Gene Symbols: RAD21
• Immunogen: Human recombit protein fragment corresponding to amino acids 193-458 of human RAD21 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b