Invitrogen™ RAD23B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529840

Catalog No. PIPA529840

Description

Recommended positive controls: A431, Jurkat, Raji, HeLa. Predicted reactivity: Human (99%), Mouse (92%), Rat (93%), Xenopus laevis (80%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.

Specifications

• Antigen: RAD23B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rad23b
• Gene Alias: 0610007D13Rik; AV001138; HHR23B; HR23B; Mhr23b; P58; RAD23 homolog B (S. cerevisiae); RAD23 homolog B, nucleotide excision repair protein; RAD23, yeast homolog of, B; RAD23B; RAD23b homolog; RAD23b homolog (S. cerevisiae); UV excision repair protein RAD23 homolog B; XP-C repair complementing complex 58 kDa; XP-C repair complementing protein; XP-C repair-complementing complex 58 kDa protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5887
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P54727
• Gene Symbols: Rad23b
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 164 and 409 of Human RAD23B.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG