Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. ABE1959

MilliporeSigma™ RAD9A, Rabbit, Unlabeled, Polyclonal,

Catalog No. ABE1959 Shop All MilliporeSigma Products
Change view
Click to view available options
Quantity:
100 μg
Conjugate:
Unconjugated
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity Conjugate
ABE1959 100 μg Unconjugated
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. ABE1959 Supplier MilliporeSigma™ Supplier No. ABE1959
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Cell cycle checkpoint control protein RAD9A (EC 3.1.11.2; UniProt Q9Z0F6; also known as DNA repair exonuclease rad9 homolog A, mRAD9, Rad9-like protein) is encoded by the Rad9a (also known as Rad9) gene (Gene ID 19367) in murine species. RAD9A is a component of the trimeric PCNA-like 9-1-1 complex (Rad9A, Rad1, and Hus1) and plays an important role in maintaining genomic integrity. RAD9A participates in both ATR and ATM signaling pathways-mediated cell cycle checkpoints in mitosis. Evidences indicate that RAD9A participates in DNA damage repair by interacting with proteins involved in base excision repair, mismatch repair and homologous recombination repair. RAD9A is shown to colocalize with γH2AX following DNA damage induction in an ATM-independent manner, and RAD9A inactivation delays the appearance of ionizing radiation-induced γH2AX foci. Rad9a-knockout causes embryonic lethality in mice due to increased apoptotic activity and reduced cellular proliferation, while mice heterozygous for Rad9a are prone to spontaneous and radiation-induced cataractogenesis. In addition, conditional knockout in keratinocytes causes enhanced susceptibility to carcinogen-induced skin tumors, while conditional Rad9a deletion in undifferentiated spermatogonia results in drastic effects on meiosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RAD9A
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Rad9a, Rad9
Gene Accession No. Q9Z0F6
Host Species Rabbit
Immunogen GST-tagged recombinant full-length mouse RAD9A.
Purification Method Protein A Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics & Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_035367
Test Specificity This rabbit polyclonal antibody detected nuclear RAD9A immunoreactivity in human and mouse tissue sections.
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt..
Form Purified
Show More Show Less

For Research Use Only. Not for use in diagnostic procedures.

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.