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RAF1/c-RAF Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A301519A

Encompass_Preferred

Catalog No. 50-156-0592


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine and Orangutan

Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noo syndrome 5 and LEOPARD syndrome 2.
Specifications

Specifications

RAF1/c-RAF
Polyclonal
Unconjugated
RAF1
CRAF, NS5, Raf-1, c-Raf
Rabbit
Antigen affinity chromatography
RUO
110157, 5894
4° C
Liquid
Immunoprecipitation, Western Blot
0.2 mg/ml
TBS with 0.1% BSA and 0.09% sodium azide
P04049, Q99N57
RAF1
Between 598 and 648
100 μL
Primary
Human, Mouse
Antibody
IgG
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