Invitrogen™ RAGE Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589548

Catalog No. PIPA589548

Description

Immunogen sequence: IGEPLVLKCK GAPKKPPQRL EWKLNTGRTE AWKVLSPQGG GPWDSVARVL PNGSLFLPAV GIQDEGIFRC QAMNRNGKET KSNYRVRVYQ IPGKPEIVDS ASELTAGVPN KVGTCVSEGS YPAGTLSWHL DGKPLVPNEK GVSVKEQTRR HPETGLFTLQ SELMVTPARG GDPRPTFSCS FSPGLPRHRA LRTAPIQPRV WEPVPLEEVQ LVVEPEGGAV APGGTVTLTC EVPAQPSPQI HWMKDGVPLP LPPSPVLILP EIGPQDQGTY SCVATHSSHG PQESRAVSIS IIEPGEEGPT A; Positive Samples: A-549, NCI-H460, Mouse small intestine, Rat kidney; Cellular Location: Cell membrane, Single-pass type I membrane protein.

The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor belonging to the immunoglobulin superfamily. RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-β peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. The interaction between RAGE and its ligands triggers intracellular signaling pathways such as NF-?B activation, leading to inflammatory responses and oxidative stress. In the context of chronic diseases like diabetes, Alzheimer's, and cardiovascular diseases, RAGE is a critical mediator, linking metabolic disturbance to cellular dysfunction. Therapeutic targeting of RAGE signaling is under investigation, aiming to mitigate its contribution to inflammatory and degenerative diseases.

Specifications

• Antigen: RAGE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AGER
• Gene Alias: advanced glycation end product receptor; advanced glycation end-product receptor; advanced glycation end-products receptor; advanced glycosylation end product-specific receptor; advanced glycosylation end product-specific receptor variant 2; advanced glycosylation end product-specific receptor variant 3; advanced glycosylation end product-specific receptor variant 4; advanced glycosylation end product-specific receptor variant 5; advanced glycosylation end-product specific receptor; Ager; MAPK/MAK/MRK overlapping kinase; MOK; MOK protein kinase; RAGE; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; RAGE/AGER; RAGE1; RAGE-1; RAGE-4 ORF3; receptor for advanced glycation endproducts; receptor for advanced glycation end-products variant 20; receptor for advanced glycosylation end products; receptor of advanced glycosylation end products of proteins; immunoglobulin superfamily; MHC class II; MHC class III; renal cell carcinoma antigen; renal tumor antigen 1; SCARJ1; sRAGE; STK30
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11596, 177, 81722
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.24 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q15109, Q62151, Q63495
• Gene Symbols: AGER
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-330 of human AGER (NP_0011271).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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