RAN Mouse anti-Human, Monkey, Rat, Clone:8D1H12, Abnova™

Catalog No.	Quantity
89-333-591	100 μg

Catalog No. 89-333-591 Supplier Abnova Corporation Supplier No. MAB17210

Description

Mouse monoclonal antibody raised against recombinant human RAN.

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy′s disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy′s disease. [provided by RefSeq]

Specifications

• Antigen: RAN
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 8D1H12
• Conjugate: Unconjugated
• Description: RAN, member RAS oncogene family
• Dilution: ELISA (1:10000)
  Western Blot (1:500-1:2000)
  Immunohistochemistry (1:200-1:1000)
  Immunocytochemistry
  Flow Cytometry (1:200-1:400)
  The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% sodium azide)
• Gene: RAN
• Gene Alias: ARA24, Gsp1, TC4
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acid 1-216 of human RAN from E. coli.
• Quantity: 100 μg
• Gene ID (Entrez): 5901
• Target Species: Human, Monkey, Rat
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1