Invitrogen™ RANBP10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110267

Catalog No. PIPA5110267

Description

Immunogen sequence: YPGSPSLSPR HGPSSSHMHN TGADSPSCSN GVASTKSKQN HSKYPAPSSS SSSSSSSSSS SPSSVNYSES NSTDSTKSQH HSSTSNQETS DSEMEMEAEH YPNGVLGSMS TRIVNGAYKH EDLQTDESSM DDRHPR.

The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets where it localizes to polymerized noncentrosomal microtubules. RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase, suggesting that RANBP10 may also be involved in these activities. RANBP10 depletion in vitro caused the disturbance of polymerized filaments in MKs and platelets in RANBP10-null mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.

Specifications

• Antigen: RANBP10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RANBP10
• Gene Alias: 4432417N03Rik; KIAA1464; RAN binding protein 10; ran-binding protein 10; RANBP10; rangef; RGD1311587
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57610, 74334
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.59 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q6VN19, Q6VN20
• Gene Symbols: RANBP10
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 362-497 of human RANBP10 (NP_065901.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG