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Invitrogen™ RANBP10 Polyclonal Antibody
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Catalog No. PIPA5110267
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100 μL
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Catalog No. Quantity
PIPA5110267 100 μL
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Catalog No. PIPA5110267 Supplier Invitrogen™ Supplier No. PA5110267
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YPGSPSLSPR HGPSSSHMHN TGADSPSCSN GVASTKSKQN HSKYPAPSSS SSSSSSSSSS SPSSVNYSES NSTDSTKSQH HSSTSNQETS DSEMEMEAEH YPNGVLGSMS TRIVNGAYKH EDLQTDESSM DDRHPR.

The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets where it localizes to polymerized noncentrosomal microtubules. RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase, suggesting that RANBP10 may also be involved in these activities. RANBP10 depletion in vitro caused the disturbance of polymerized filaments in MKs and platelets in RANBP10-null mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RANBP10
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.59 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene RANBP10
Gene Accession No. Q6VN19, Q6VN20
Gene Alias 4432417N03Rik; KIAA1464; RAN binding protein 10; ran-binding protein 10; RANBP10; rangef; RGD1311587
Gene Symbols RANBP10
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 362-497 of human RANBP10 (NP_065901.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57610, 74334
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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