RANGAP1 Mouse anti-Human, Clone:4F9E2, Abnova™

Catalog No.	Quantity
89-333-188	100 μg

Catalog No. 89-333-188 Supplier Abnova Corporation Supplier No. MAB16611

Description

Mouse monoclonal antibody raised against recombinant human RANGAP1.

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq]

Specifications

• Antigen: RANGAP1
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 4F9E2
• Conjugate: Unconjugated
• Description: Ran GTPase activating protein 1
• Dilution: ELISA (1:10000)
  Western Blot (1:500-1:2000)
  The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% sodium azide)
• Gene: RANGAP1
• Gene Alias: Fug1, KIAA1835, MGC20266, SD
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acid 359-587 of human RANGAP1 from E. coli.
• Quantity: 100 μg
• Gene ID (Entrez): 5905
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1