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RanGAP1 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501572353
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50-157-2353 100 μL
50-157-2354 10 μL
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Catalog No. 50-157-2353 Supplier Bethyl Laboratories, Inc Supplier No. IHC00586
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Chimpanzee and Northern white-cheeked gibbon

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1, 000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.

Specifications

Antigen RanGAP1
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene RANGAP1
Gene Accession No. P46060
Gene Alias Fug1, KIAA1835, MGC20266, SD
Gene Symbols RANGAP1
Host Species Rabbit
Immunogen Between 400 and 450
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5905
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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