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RanGAP1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501561585
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50-156-1585 100 μL
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Catalog No. 50-156-1585 Supplier Bethyl Laboratories, Inc Supplier No. A302027A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1, 000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.

Specifications

Antigen RanGAP1
Applications Immunohistochemistry, Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene RANGAP1
Gene Accession No. P46060
Gene Alias Fug1, KIAA1835, MGC20266, SD
Gene Symbols RANGAP1
Host Species Rabbit
Immunogen Between 400 and 450
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5905
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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