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Invitrogen™ RAP1GAP Polyclonal Antibody
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Catalog No. PIPA529841
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100 μL
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Catalog No. Quantity
PIPA529841 100 μL
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Catalog No. PIPA529841 Supplier Invitrogen™ Supplier No. PA529841
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: mouse brain, rat brain. Predicted reactivity: Human (99%), Mouse (97%), Rat (98%), Zebrafish (81%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Rap1GAP specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between G alpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and also attenuates the ability of activated G alpha z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to G alpha z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1, resulting in the activation of ERK/MAPK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RAP1GAP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.51 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene RAP1GAP
Gene Accession No. A2ALS5, P47736
Gene Alias 1300019I11Rik; 2310004O14Rik; AI427470; ARPP-90; KIAA0474; RAP1 GTPase activating protein; Rap1 GTPase-activating protein; rap1 GTPase-activating protein 1; Rap1, GTPase-activating protein 1; Rap1ga1; Rap1GAP; Rap1GAP1; RAP1GAPII; RAPGAP
Gene Symbols RAP1GAP
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Rap1GAP. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 110351, 313644, 5909
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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