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RAP1GAP Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 191741AP

Catalog No. 50-173-2359

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Rap1GAP specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between G alpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and also attenuates the ability of activated G alpha z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to G alpha z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1, resulting in the activation of ERK/MAPK.


0.15 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
A2ALS5, P47736
KIAA0474, RAP1 GTPase activating protein, RAP1GA1, RAP1GAP, RAP1GAP1, RAP1GAPII, RAPGAP
150 μL
110351, 313644, 5909
Immunocytochemistry, Immunofluorescence, Western Blot
RAP1GAP Fusion Protein Ag5576
Antigen Affinity Chromatography
Human, Mouse, Rat
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