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Invitrogen™ RAP1GAP Recombinant Rabbit Monoclonal Antibody (8V9I6)
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Catalog No. PIMA542831
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100 μL
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PIMA542831 100 μL
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Catalog No. PIMA542831 Supplier Invitrogen™ Supplier No. MA542831
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: BxPC-3, U-87MG, Mouse brain, Rat brain. The target is usually found in the following locations: Golgi apparatus membrane, Peripheral membrane protein. Immunogen sequence: MIEKMQGSRM DEQRCSFPPP LKTEEDYIPY PSVHEVLGRE GPFPLILLPQ FGGYWIEGTN HEITSIPETE PLQSPTTKVK LECNPTARIY RKHFLGKEHF.

Rap1GAP specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between G alpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and also attenuates the ability of activated G alpha z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to G alpha z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1, resulting in the activation of ERK/MAPK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RAP1GAP
Applications ELISA, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 8V9I6
Concentration 0.66 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene RAP1GAP
Gene Accession No. A2ALS5, P47736
Gene Alias 1300019I11Rik; 2310004O14Rik; AI427470; ARPP-90; KIAA0474; RAP1 GTPase activating protein; Rap1 GTPase-activating protein; rap1 GTPase-activating protein 1; Rap1, GTPase-activating protein 1; Rap1ga1; Rap1GAP; Rap1GAP1; RAP1GAPII; RAPGAP
Gene Symbols RAP1GAP
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Rap1GAP (P47736).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 110351, 313644, 5909
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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