Invitrogen™ RAR gamma-1,2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121101

Catalog No. PIPA5121101

Description

Positive test controls include: Mouse lung, Rat kidney. The target is usually found in the following locations: Nucleus. Immunogen sequence: KKEVKEEGSP DSYELSPQLE ELITKVSKAH QE.

Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma. Two main isoforms of RAR gamma exist: RAR gamma-1 has been found to be predominantly expressed in skin, while RAR gamma-2 has been found early in embryogenesis and in embryonal carcinoma cells. RAR gamma is also known as RARD. The corresponding gene for the retinoic acid receptor gamma 1 is NR1B3.

Specifications

• Antigen: RAR gamma-1,2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RARG
• Gene Symbols: RARG
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 168-199 of human RARG (NP_0009571).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Concentration: 1.82 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P13631, P18911
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19411, 5916, 685072
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid