Invitrogen™ Ras (K117N Mutant) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578090

Catalog No. PIPA578090

Description

Positive Control: Human Ras (K117N Mutant specific)-transfected 293T whole cell extracts Predicted Reactivity: Mouse (100%), Rat (100%), Dog (100%), Pig (100%), Chicken (100%), Bovine (100%), Guinea pig (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Ras is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. The process of shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in Ras gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

Specifications

• Antigen: Ras (K117N Mutant)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NRAS
• Gene Alias: ALPS4; CMNS; GTPase NRas; HRAS1; NCMS; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; NRAS; N-ras; N-ras protein part 4; NRAS1; NS6; Transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4893
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P01111
• Gene Symbols: NRAS
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Ras (K117N Mutant Specific). The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov