Invitrogen™ RASA4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531885

Catalog No. PIPA531885

Description

Recommended positive controls: 293T, A431, HeLa. Predicted reactivity: Mouse (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: RASA4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RASA4
• Gene Alias: AA793972; AW112107; BB079060; Ca2+promoted Ras inactivator; Ca2+-promoted Ras inactivator; calcium-promoted RAS inactivator; Capri; GAPL; Kiaa0538; Ras GTPase-activating protein 4; RAS p21 protein activator 4; RASA4; RasGAP-activating-like protein 2; RGD1565457
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10156
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.9 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O43374
• Gene Symbols: RASA4
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 20 and 803 of Human RASA4.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov