Invitrogen™ RASA4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110274

Catalog No. PIPA5110274

Description

Immunogen sequence: HLPPTFHAVA FYVMDEDALS RDDVIGKVCL TRDTIASHPK GFSGWAHLTE VDPDEEVQGE IHLRLEVWPG ARACRLRCSV LEARDLAPKD RNGTSDPFVR VRYKGRTRET SIVKKSCYPR WNETFEFELQ EGAMEALCVE AWDWDLVSRN DFLGKVVIDV QRLRVVQQEE GWFRLQPDQS KSRRHDEGNL GSLQLEVRLR DETVLPSSYY QPLVHLLCHE VKLGMQGPGQ L.

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: RASA4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RASA4
• Gene Alias: AA793972; AW112107; BB079060; Ca2+promoted Ras inactivator; Ca2+-promoted Ras inactivator; calcium-promoted RAS inactivator; Capri; GAPL; Kiaa0538; Ras GTPase-activating protein 4; RAS p21 protein activator 4; RASA4; RasGAP-activating-like protein 2; RGD1565457
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10156, 288589, 54153
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.74 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O43374, Q6PFQ7
• Gene Symbols: RASA4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human RASA4 (NP_008920.5).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov