Invitrogen™ RASAL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA550867

Catalog No. PA550867

Description

The antibody detects endogenous levels of total RASAL1 protein.

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described.

Specifications

• Antigen: RASAL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rasal1
• Gene Alias: GAP1 like protein; MRASAL; Ras GTPase-activating-like protein; RAS protein activator like 1; RAS protein activator like 1 (GAP1 like); Rasal; Rasal1; RasGAP-activating-like protein 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8437
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O95294
• Gene Symbols: Rasal1
• Immunogen: Fusion protein corresponding to residues near the N terminal of human RAS protein activator like 1 (GAP1 like).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG