Invitrogen™ RASIP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104062

Catalog No. PIPA5104062

Description

Antibody detects endogenous levels of total RASIP1.

Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.

Specifications

• Antigen: RASIP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RASIP1
• Gene Alias: 1110025D03Rik; 2610025P08Rik; AI853551; RAIN; Ras interacting protein 1; ras-interacting protein 1; Rasip1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 292912, 54922
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q5U651
• Gene Symbols: RASIP1
• Immunogen: A synthesized peptide derived from human RASIP1(Accession Q5U651), corresponding to amino acid residues V641-L691.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov