Invitrogen™ RASSF1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142452

Catalog No. PIPA5142452

Description

Additional Information: This antibody is expected to recognize reported isoforms A, C and D (NP_009113.3; NP_733831.1; NP_733832.1) . This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Specifications

• Antigen: RASSF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RASSF1
• Gene Alias: 123F protein; 123F2; AA536941; AU044980; cardiac-specific ras association domain family 1 protein; NORE2A; pancreas-specific ras association domain family 1 protein; protein 123F2; Ras association (RalGDS/AF-6) domain family 1; Ras association (RalGDS/AF-6) domain family member 1; Ras association domain family 1; Ras association domain family member 1; ras association domain-containing protein 1; Rassf1; Rassf1A; RASSF1A tumor suppressor; Rassf1B; Rassf1C; RDA32; REH3P21; tumor suppressor protein RDA32; wu:fc17f02; WUGSC:H_LUCA12.5; zgc:112224; zgc:92505; zgc:92505 protein
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 11186
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9NS23
• Gene Symbols: RASSF1
• Immunogen: Peptide with sequence C-SQAEIEQKIKEYN (aa 135-147).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG