AID Rat anti-Human, Alexa Fluor 647, Clone: EK2-5G9, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 565785

Catalog No. BDB565785

Description

The EK2-5G9 monoclonal antibody specifically binds to human Activation-induced cytidine deaminase (AICDA), also known as AID, or Single-stranded DNA cytosine deaminase. AID is an enzyme that preferentially acts upon certain DNA sequence motifs, such as those located in immunoglobulin variable regions, to induce cytidine-to-uracil mutations. AID-induced mutations initiate both somatic hypermutation (SHM) and class switch recombination (CSR) of the immunoglobulin genes in activated B cells during immune responses. While essential for immunoglobulin gene diversification, dysregulated AID activity can result in genomic instability and oncogenic transformation. Originally thought to be B-cell specific, AID now appears to be abnormally expressed in several epithelial cancers. AID may also play roles in DNA demethylation.

Specifications

• Antigen: AID
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: AID; ARP2; CDA2; HEL-S-284; HIGM2; Cytidine aminohydrolase
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG2b κ

• Applications: Flow Cytometry, Immunofluorescence, Immunocytochemistry
• Clone: EK2-5G9
• Conjugate: Alexa Fluor 647
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Human AID (185-198) Peptide
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.