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AID Rat anti-Human, Alexa Fluor 647, Clone: EK2-5G9, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 565785

Catalog No. BDB565785

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The EK2-5G9 monoclonal antibody specifically binds to human Activation-induced cytidine deaminase (AICDA), also known as AID, or Single-stranded DNA cytosine deaminase. AID is an enzyme that preferentially acts upon certain DNA sequence motifs, such as those located in immunoglobulin variable regions, to induce cytidine-to-uracil mutations. AID-induced mutations initiate both somatic hypermutation (SHM) and class switch recombination (CSR) of the immunoglobulin genes in activated B cells during immune responses. While essential for immunoglobulin gene diversification, dysregulated AID activity can result in genomic instability and oncogenic transformation. Originally thought to be B-cell specific, AID now appears to be abnormally expressed in several epithelial cancers. AID may also play roles in DNA demethylation.



Alexa Fluor 647
Aqueous buffered solution containing ≤0.09% sodium azide.
IgG2b, κ
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry, Immunocytochemistry, Immunofluorescence
AID; ARP2; CDA2; HEL-S-284; HIGM2; Cytidine aminohydrolase
Affinity Purified
Human AID (185-198) Peptide
Affinity Chromatography
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