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CD115 Rat anti-Human, Alexa Fluor 647, Clone: 9-4D2-1E4, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 564945

Catalog No. BDB564945


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Description

Description

The 9-4D2-1E4 monoclonal antibody specifically binds to CD115 which is also known as Colony stimulating factor 1 receptor (CSF-1R) or Macrophage colony-stimulating factor 1 receptor (M-CSFR). This type I transmembrane glycoprotein is a receptor tyrosine kinase (RTK) that belongs to the Ig superfamily. It is expressed on a variety of cells including those committed to the mononuclear phagocyte lineage, such as, monocytes, macrophages, and osteoclasts. CSF-1 binds to and signals through CSF-1R homodimers which undergo tyrosine autophosphorylation and transduce downstream signaling pathways resulting in cytoskeletal reorganization and gene expression. CSF-1R activation stimulates the proliferation, differentiation, and survival of cells within the mononuclear phagocyte system. Acting through CD115, CSF-1 induces macrophage spreading and motility, and in combination with RANKL, CSF-1 drives the differentiation of mononuclear phagocytes to become osteoclasts. Interleukin-34 (IL-34) is another ligand for CD115 that can induce similar, as well as, some different biological responses by CD115-positive target cells.

Specifications

Specifications

CD115
9-4D2-1E4
CSF-1R; CSF1R; C-FMS; FMS; FIM2
Affinity Purified
Human CD115 Transfected Cell Line
Affinity Chromatography
RUO
Primary
Human
Flow Cytometry
Alexa Fluor 647
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Rat
IgG1, κ
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Documents
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