CD127 Rat anti-Mouse, PE, Clone: SB/199, BD

Catalog No.	Quantity
BDB552543	0.2 mg

Catalog No. BDB552543 Supplier BD Biosciences Supplier No. 552543

Description

Rat Monoclonal Antibody

The SB/199 monoclonal antibody specifically binds to mouse CD127, the 65-75 kDa type-I transmembrane protein IL-7Rα. The high affinity IL-7 receptor complex is composed of at least two transmembrane proteins, IL-7Rα and CD132, the common γ chain. CD127 has some sequence homology to the cytokine receptor superfamily (also known as the hematopoietin receptor superfamily). Micelacking CD127 display profoundly impaired development of the B and T lymphoid cell lineages, but display no obvious non-lymphoid abnormalities. IL-7Rα is expressed on common lymphoid progenitors and early stages of B lineage development in the bone marrow, on the earliest thymocyte progenitors, on CD4-CD8- double-negative and CD4+ and CD8+ single-positive thymocytes, and on most peripheral T lymphocytes. Intestinal intraepithelial lymphocytes with low-density γδ TCR upregulate CD127 expression in response to IL-2, which may be secreted by neighboring αβ TCR-bearing T cells.

Specifications

• Antigen: CD127
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: SB/199
• Concentration: 0.2mg/mL
• Conjugate: PE
• Description: Interleukin-7 receptor alpha chain; IL-7R alpha; IL-7RA; IL-7Rα; Il7r
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Rat
• Immunogen: BALB/c mouse pre-B cell line 1A9
• Purification Method: Affinity Purified
• Quantity: 0.2 mg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Mouse
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG2b κ

For Research Use Only.