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CD268 (BAFF-R) Rat anti-Mouse, PE, Clone: 7H22-E16, BD

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BDB565783 50 μg
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Catalog No. BDB565783 Supplier BD Biosciences Supplier No. 565783
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Description

Rat Monoclonal Antibody

The 7H22-E16 monoclonal antibody specifically binds to CD268, which is also known as, B cell-activating factor receptor (BAFF-R), or BAFF Receptor 3 (BR3). CD268 is a type III transmembrane protein that is likewise known as Tumor necrosis factor receptor superfamily member 13C (Tnfrsf13c). CD268/BAFF-R is a receptor for CD257 (also known as, BAFF, Blys, TALL-1, or THANK) and is expressed on B cells and a subset of activated/memory CD4+ T cells. B cells express two other BAFF receptors, CD267/TACI, or CD269/BCMA, at various times during their differentiation. CD268/BAFF-R expression starts at the transitional stage of B cell development and increases throughout B cell maturation. CD267/BAFF-R mediates most BAFF-dependent functions including B cell survival, the activation of B cell proliferation and immunoglobulin secretion, and the costimulation of T cells. Overexpression of BAFF in mice and humans is associated with autoimmunity, whereas CD268/BAFF-R deficiency may cause severe impairment in humoral responses.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD268 (BAFF-R)
Applications Flow Cytometry
Classification Monoclonal
Clone 7H22-E16
Concentration 0.2mg/mL
Conjugate PE
Description Tnfrsf13c; TR13C; BAFF-R; Baffr; Bcmd; Bcmd-1; BLyS receptor 3; Br3; Lvis22
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse BAFF-R Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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