CD281 (TLR1) Rat anti-Mouse, Brilliant Violet 421, Clone: TR23, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 565792
The TR23 monoclonal antibody specifically binds to CD281, which is also known as Toll-like receptor 1 (TLR1), or Toll/interleukin-1 receptor-like protein (TIL). CD281 is an ~98 kDa type I transmembrane glycoprotein that belongs to the Toll-like receptor (TLR) family. CD281 functions as a pattern recognition receptor (PRR) for pathogen-associated molecular patterns (PAMP) that are broadly expressed by microbial pathogens and plays essential roles in innate and adaptive immunity. In the process of binding microbial ligands, such as triacylated microbial lipopeptides, TLR1 associates with CD282 (TLR2). CD281 is expressed on B cells, monocytes/macrophages, and dendritic cells. CD281/TLR1-deficient mice display impaired production of inflammatory cytokines in response to microbial ligands.
The antibody was conjugated to BD Horizon BV421 which is part of the BD Horizon Brilliant Violet family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue filter set (eg, 450/50-nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.
|Brilliant Violet 421|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Cd281; Tlr1; Toll-like receptor 1; TIL; Toll/interleukin-1 receptor-like|
|Mouse TLR1 Transfected Cell Line|