CYP2D6, Rat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-126-667	100 μL

Catalog No. 89-126-667 Supplier Abnova Corporation Supplier No. PAB24990

Description

Rabbit polyclonal antibody raised against synthetic peptide of CYP2D6.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Antigen: CYP2D6
• Applications: Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of CYP2D6.
• Dilution: Immunohistochemistry (1:50-1:200) Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.2 (0.05% sodium azide)
• Gene: CYP2D6
• Gene Alias: CPD6/CYP2D/CYP2D@/CYP2DL1/MGC120389/MGC120390/P450-DB1/P450C2D/P450DB1
• Gene Symbols: CYP2D6
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to amino acids 241-290 of human CYP2D6.
• Purification Method: Antigen affinity purification
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1565
• Test Specificity: CYP2D6 polyclonal antibody detects endogenous levels of CYP2D6 protein.
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only