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Rat anti-Endorepellin/Perlecan/Heparan Sulfate Proteoglycan, Clone: A7L6, Novus Biologicals™

Rat Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2444480.1MG

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Catalog No. NBP24444801

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Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Monoclonal antibody specifically detects Endorepellin/Perlecan/Heparan Sulfate Proteoglycan in Human, Mouse, Porcine, Fish, Monkey samples. It is validated for Flow Cytometry, Immunohistochemistry-Paraffin, SDS-Page, Immunofluorescence.


Endorepellin/Perlecan/Heparan Sulfate Proteoglycan
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Murine EHS laminin preparation
Protein A or G purified
Human, Mouse, Porcine, Fish, Monkey
Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 1 - 2 ug/ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
basement membrane-specific heparan sulfate proteoglycan core protein, endorepellin (domain V region), heparan sulfate proteoglycan 2, HSPG, perlecan, perlecan proteoglycan, PLCSchwartz-Jampel syndrome 1 (chondrodystrophic myotonia), PRCAN, SJA, SJS, SJS1
IgG2a Kappa
0.1 mg
Store at 4C.
This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
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