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CD11a Rat anti-Mouse, Brilliant Violet 605, Clone: 2D7, BD Optibuild™

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BDB740340 50 μg
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Catalog No. BDB740340 Supplier BD Biosciences Supplier No. 740340
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Description

Rat Monoclonal Antibody

The 2D7 monoclonal antibody specifically binds to the 180-kDa α L chain of LFA-1 (CD11a/CD18, α L β 2 integrin), a heterodimeric surface glycoprotein expressed on almost all leukocytes. CD8a+CD8b- intestinal intraepithelial T lymphocytes, which are believed to be thymus independent, do not express CD11a. LFA-1 mediates a variety of heterotypic and homotypic intracellular adhesions through interaction with ICAM-1 (CD54) and ICAM-2 (CD102), including participation in the immunological synapses between CD8+ T lymphocytes and antigen-presenting cells. mAb 2D7 has been reported to block an in vitro allogeneic mixed-leukocyte reaction. The 2D7 and M17/4 (Cat. No. 553337, for the NA/LE™ format) antibodies are reported to recognize different epitopes of the CD11a molecule.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD11a
Applications Flow Cytometry
Classification Monoclonal
Clone 2D7
Concentration 0.2mg/mL
Conjugate Brilliant Violet 605
Description Itgal; Integrin alpha-L; Integrin αL; ITAL; LFA-1A; LFA-1α; Ly-15
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Not Reported
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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