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CD131 Rat anti-Mouse, Brilliant Violet 421, Clone: JORO50, BD Optibuild™

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 740050

Catalog No. BDB740050


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Description

Description

The JORO50 monoclonal antibody specifically recognizes the extracellular regions of the mouse CD131/ βc (Bc, AIC2B, Il3rb1, Csf2rb1) and βIL3 (BIL3, AIC2A, Il3rb2, Csf2rb2) cytokine receptor subunits. A variety of mouse cell ty pes, including multipotential hematopoietic stem cells, mast cells, megakaryocytes, eosinophils, erythroblasts, pre-B cells, and osteoclasts, express βIL-3 and βc subunits. Either βIL-3 or βc can combine with the IL-3Rα chain to form two distinct, functional (i.e., signaling), high affinity receptors for mouse IL-3. The βIL-3 subunit by itself can bind mouse IL-3 with low affinity whereas the βc subunit can not. βc (but not βIL-3) can combine with the IL-5Rα (CD125) and GM-CSFRα (CD116) subunits to form hig h affinity, signaling receptors for mouse IL-5 or GM-CSF, respectively. The immunogen used to generate the JORO50 hybridoma was the bone marrow-derived, C4-77 pro-T lymphocyte clone.

Specifications

Specifications

CD131
JORO50
Brilliant Violet 421
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG1, κ
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
CD131, βc, Bc, AIC2B, Il3rb1, Csf2rb1; βIL3, BIL3, AIC2A, Il3rb2, Csf2rb2
Affinity Purified
Bone Marrow-Derived C4-77 Pro-T Lymphocyte Clone
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Murine
Documents
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