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CD160 Rat anti-Mouse, Brilliant Violet 711, Clone: CNX46-3, BD Optibuild™

Catalog No. BDB740828 Shop All BD Biosciences Products
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BDB740828 50 μg
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Catalog No. BDB740828 Supplier BD Biosciences Supplier No. 740828
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Description

Rat Monoclonal Antibody

The CNX46-3 monoclonal antibody specifically binds to mouse CD160, also known as Natural Killer Cell Receptor BY55. CD160 is a glycosyolphosphatidylinositol-anchored membrane glycoprotein that contains a single Ig domain. This member of the Ig Superfamily was the first identified as a MHC Class I antigen-specific Ig-like Receptor that was expressed by mouse NK cells. As a receptor, CD160 can bind to classical and non-classical MHC class I molecules with low affinity. As a ligand, CD160 can bind to HVEM (Herpes Virus Entry Mediator, a TNF Receptor Family Member). CD160 is expressed on a subset of NK cells, NKT cells, activated CD8+ T cells and TCR γδ T cells. The functions of CD160 have been reported to regulate NK cell activation both positively and negatively, depending on the stimulus.

The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 711-nm. BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors. However, the spillover can be corrected through compensation as with any other dye combination.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD160
Applications Flow Cytometry
Classification Monoclonal
Clone CNX46-3
Concentration 0.2mg/mL
Conjugate Brilliant Violet 711
Description Cd160; By55; Natural killer cell receptor BY55
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse CD160 Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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