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CD3 molecular complex Rat anti-Mouse, Brilliant Violet 650, Clone: 17A2, BD Optibuild™

Catalog No. BDB740530 Shop All BD Biosciences Products
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BDB740530 50 μg
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Catalog No. BDB740530 Supplier BD Biosciences Supplier No. 740530
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Description

Rat Monoclonal Antibody

The 17A2 monoclonal antibody specifically binds to the T-cell receptor-associated CD3 complex that is expressed on many thymocytes and mature T lymphocytes. Plate-bound 17A2 antibody has been reported to induce IL-2 production by cultured T cells in the absence of accessory cells. The binding of the 17A2 antibody to T cells can be blocked by the anti-CD3e mAb 145-2C11 (Cat. No. 557306/553058/550275). This suggests that the 17A2 antibody recognizes an epitope of the CD3 epsilon chain. In vivo treatment with 17A2 antibody has been reported to partially deplete T lymphocytes and temporarily down-modulates CD3 expression on T cells.

The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 650-nm. BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors. However, the spillover can be corrected through compensation as with any other dye combination.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD3 molecular complex
Applications Flow Cytometry
Classification Monoclonal
Clone 17A2
Concentration 0.2mg/mL
Conjugate Brilliant Violet 650
Description CD3; CD3 epsilon; Cd3e; CD3ε; T3e
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen γδ TCR-positive T-T hybridoma D1
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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